|Other Names||Probable crossover junction endonuclease EME2, 3122-, EME2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Interacts with MUS81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures.|
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Provided below are standard protocols that you may find useful for product applications.
EME2 forms a heterodimer with MUS81 (MIM 606591) thatfunctions as an XPF (MIM 278760)-type flap/fork endonuclease in DNArepair (Ciccia et al., 2007 [PubMed 17289582]).
Ciccia, A., et al. Mol. Cell 25(3):331-343(2007)Ciccia, A., et al. J. Biol. Chem. 278(27):25172-25178(2003)Daniels, R.J., et al. Hum. Mol. Genet. 10(4):339-352(2001)
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