|Other Names||Insulin gene enhancer protein ISL-1, Islet-1, ISL1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1 (By similarity).|
|Tissue Location||Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain|
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Provided below are standard protocols that you may find useful for product applications.
ISL1 is a member of the LIM/homeodomain familyof transcription factors. The encoded protein binds to the enhancerregion of the insulin gene, among others, and may play an importantrole in regulating insulin gene expression. The encoded protein iscentral to the development of pancreatic cell lineages and may alsobe required for motor neuron generation. Mutations in this genehave been associated with maturity-onset diabetes of the young.
De Luca, A., et al. Clin. Genet. (2010) In press :Davis, O.S., et al. Behav. Genet. (2010) In press :Genead, R., et al. Stem Cell Res 4(1):69-76(2010)Stevens, K.N., et al. PLoS ONE 5 (5), E10855 (2010) :Zhang, H., et al. J. Mol. Biol. 392(3):566-577(2009)
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