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TP53BP2 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q13625
Clone Names 100525188
Peptide ID 100525188
Additional Information
Gene ID 7159
Other Names Apoptosis-stimulating of p53 protein 2, Bcl2-binding protein, Bbp, Renal carcinoma antigen NY-REN-51, Tumor suppressor p53-binding protein 2, 53BP2, p53-binding protein 2, p53BP2, TP53BP2, ASPP2, BBP
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TP53BP2
Synonyms ASPP2, BBP
Function Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.
Cellular Location Cytoplasm, perinuclear region. Nucleus. Note=Predominantly found in the perinuclear region. Some small fraction is nuclear. Sequester in the cytoplasm on overexpression of DDX42
Tissue Location Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte. Reduced expression in breast carcinomas expressing a wild-type TP53 protein. Overexpressed in lung cancer cell lines.
Research Areas
Citations (0)

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TP53BP2 is a member of the ASPP(apoptosis-stimulating protein of p53) family of p53 interactingproteins. The protein contains four ankyrin repeats and an SH3domain involved in protein-protein interactions. It is localized tothe perinuclear region of the cytoplasm, and regulates apoptosisand cell growth through interactions with other regulatorymolecules including members of the p53 family. Multiple transcriptvariants encoding different isoforms have been found for this gene.


Rose, J. Phd, et al. Mol. Med. (2010) In press :Zhao, J., et al. Hepatology 51(1):142-153(2010)Hirata, H., et al. J. Urol. 182(2):721-727(2009)Kweekel, D.M., et al. Br. J. Cancer 101(2):357-362(2009)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)

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$ 80.00
Cat# BP16353a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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