|Other Names||Aldo-keto reductase family 1 member C4, 111-, 3-alpha-HSD1, 3-alpha-hydroxysteroid dehydrogenase type I, Chlordecone reductase, CDR, Dihydrodiol dehydrogenase 4, DD-4, DD4, HAKRA, AKR1C4, CHDR|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha- androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20- alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.|
|Tissue Location||Liver specific.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
AKR1C4 is a member of the aldo/keto reductasesuperfamily, which consists of more than 40 known enzymes andproteins. These enzymes catalyze the conversion of aldehydes andketones to their corresponding alcohols by utilizing NADH and/orNADPH as cofactors. The enzymes display overlapping but distinctsubstrate specificity. This enzyme catalyzes the bioreduction ofchlordecone, a toxic organochlorine pesticide, to chlordeconealcohol in liver. This gene shares high sequence identity withthree other gene members and is clustered with those three genes atchromosome 10p15-p14.
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)Li, J., et al. Breast Cancer Res. 12 (2), R19 (2010) :Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)Shen, M., et al. Environ. Mol. Mutagen. 50(4):285-290(2009)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.