|Other Names||Disks large-associated protein 4, DAP-4, PSD-95/SAP90-binding protein 4, SAP90/PSD-95-associated protein 4, SAPAP-4, DLGAP4, DAP4, KIAA0964, SAPAP4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DAP4, KIAA0964, SAPAP4|
|Function||May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.|
|Cellular Location||Membrane; Peripheral membrane protein|
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DLGAP4 is a membrane-associatedguanylate kinase found at the postsynaptic density in neuronalcells. It is a signaling molecule that can interact with potassiumchannels and receptors, as well as other signaling molecules. Theprotein encoded by this gene can interact with PSD-95 through itsguanylate kinase domain and may be involved in clustering PSD-95 inthe postsynaptic density region. The encoded protein is one of atleast four similar proteins that have been found. Alternativelyspliced transcript variants encoding different isoforms have beenfound for this gene.
Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :Rikova, K., et al. Cell 131(6):1190-1203(2007)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Grelle, G., et al. Mol. Cell Proteomics 5(2):234-244(2006)Kawabe, H., et al. J. Biol. Chem. 274(43):30914-30918(1999)
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