|Other Names||Taste receptor type 1 member 3, Sweet taste receptor T1R3, TAS1R3, T1R3, TR3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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The TAS1R3 gene encodes the human homolog of mouse Sac, amajor determinant of differences between sweet-sensitive and-insensitive mouse strains in their responsiveness to sucrose,saccharine, and other sweeteners (Max et al., 2001 [PubMed11326277]).
Assadi-Porter, F.M., et al. J. Mol. Biol. 398(4):584-599(2010)Assadi-Porter, F.M., et al. Biochim. Biophys. Acta 1798(2):82-86(2010)Chen, Q.Y., et al. Am. J. Clin. Nutr. 90 (3), 770S-779S (2009) :Chandrashekar, J., et al. Nature 444(7117):288-294(2006)Xu, H., et al. Proc. Natl. Acad. Sci. U.S.A. 101(39):14258-14263(2004)
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