|Other Names||Ran-binding protein 3, RanBP3, RANBP3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF- beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Widely expressed with high levels in testis and heart.|
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Provided below are standard protocols that you may find useful for product applications.
RANBP3 is a protein with a RanBD1 domain that isfound in both the nucleus and cytoplasm. This protein plays a rolein nuclear export as part of a heteromeric complex. Alternatetranscriptional splice variants, encoding different isoforms, havebeen characterized.
Dai, F., et al. Dev. Cell 16(3):345-357(2009)Yoon, S.O., et al. Mol. Cell 29(3):362-375(2008)Olsen, J.V., et al. Cell 127(3):635-648(2006)Hakata, Y., et al. Mol. Cell. Biol. 23(23):8751-8761(2003)Nemergut, M.E., et al. J. Biol. Chem. 277(20):17385-17388(2002)
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