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RANBP3 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H6Z4 |
|---|---|
| Clone Names | 100528129 |
| Gene ID | 8498 |
|---|---|
| Other Names | Ran-binding protein 3, RanBP3, RANBP3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RANBP3 |
|---|---|
| Function | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Widely expressed with high levels in testis and heart. |
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Provided below are standard protocols that you may find useful for product applications.
Background
RANBP3 is a protein with a RanBD1 domain that isfound in both the nucleus and cytoplasm. This protein plays a rolein nuclear export as part of a heteromeric complex. Alternatetranscriptional splice variants, encoding different isoforms, havebeen characterized.
References
Dai, F., et al. Dev. Cell 16(3):345-357(2009)Yoon, S.O., et al. Mol. Cell 29(3):362-375(2008)Olsen, J.V., et al. Cell 127(3):635-648(2006)Hakata, Y., et al. Mol. Cell. Biol. 23(23):8751-8761(2003)Nemergut, M.E., et al. J. Biol. Chem. 277(20):17385-17388(2002)
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