|Other Names||Attractin, DPPT-L, Mahogany homolog, ATRN, KIAA0548, MGCA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity).|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted|
|Tissue Location||Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T-lymphocytes Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform in peripheral blood leukocytes|
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Provided below are standard protocols that you may find useful for product applications.
Multiple transcript variants encoding different isoformsexist for this gene. One of the isoforms is a membrane-boundprotein with sequence similarity to the mouse mahogany protein, areceptor involved in controlling obesity. The other isoform is asecreted protein involved in the initial immune cell clusteringduring inflammatory responses that may regulate the chemotacticactivity of chemokines.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Radhakrishnan, Y., et al. Biol. Reprod. 81(4):647-656(2009)Nan, H., et al. Int. J. Cancer 125(4):909-917(2009)Fernandez, L.P., et al. Exp. Dermatol. 18(7):634-642(2009)Friedrich, D., et al. Biol. Chem. 388(2):155-162(2007)
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