|Other Names||Sodium/potassium/calcium exchanger 3, Na(+)/K(+)/Ca(2+)-exchange protein 3, Solute carrier family 24 member 3, SLC24A3, NCKX3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Abundant in the brain. Expressed at low levels in the aorta, uterus and intestine|
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Provided below are standard protocols that you may find useful for product applications.
Plasma membrane sodium/calcium exchangers are an importantcomponent of intracellular calcium homeostasis and electricalconduction. Potassium-dependent sodium/calcium exchangers such asSLC24A3 are believed to transport 1 intracellular calcium and 1potassium ion in exchange for 4 extracellular sodium ions (Kraev etal., 2001 [PubMed 11294880]).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Cheng, Y.C., et al. Circ Cardiovasc Genet 2(4):329-337(2009)Deloukas, P., et al. Nature 414(6866):865-871(2001)Kraev, A., et al. J. Biol. Chem. 276(25):23161-23172(2001)
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