|Other Names||5-hydroxytryptamine receptor 7, 5-HT-7, 5-HT7, 5-HT-X, Serotonin receptor 7, HTR7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in term of expression|
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The neurotransmitter, serotonin, is thought to play a rolein various cognitive and behavioral functions. The serotoninreceptor encoded by this gene belongs to the superfamily of Gprotein-coupled receptors and the gene is a candidate locus forinvolvement in autistic disorder and other neuropsychiatricdisorders. Three splice variants have been identified which encodeproteins that differ in the length of their carboxy terminal ends.
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :Corominas, R., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (1), 177-184 (2010) :Wei, Z., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry 33(3):547-551(2009)Iceta, R., et al. J. Physiol. Pharmacol. 60(1):157-164(2009)
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