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KIAA1967 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8N163
Clone Names 100430151
Peptide ID 100430151
Additional Information
Gene ID 57805
Other Names Cell cycle and apoptosis regulator protein 2, Cell division cycle and apoptosis regulator protein 2, DBIRD complex subunit KIAA1967, Deleted in breast cancer gene 1 protein, DBC-1, DBC1, p30 DBC, CCAR2, DBC1, KIAA1967
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCAR2
Synonyms DBC1, KIAA1967
Function Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3- specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation.
Cellular Location Nucleus. Note=Recruited to chromatin, post-UV irradiation
Tissue Location Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues.
Research Areas
Citations (0)

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KIAA1967 inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity.


Hiraike, H., et al. Br. J. Cancer 102(6):1061-1067(2010)Escande, C., et al. J. Clin. Invest. 120(2):545-558(2010)Kim, J.E., et al. Cell Cycle 8(18):2932-2935(2009)Cha, E.J., et al. Clin. Cancer Res. 15(13):4453-4459(2009)Li, Z., et al. J. Biol. Chem. 284(16):10361-10366(2009)

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$ 80.00
Cat# BP16400a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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