|Other Names||Ubiquitin/ISG15-conjugating enzyme E2 L6, Retinoic acid-induced gene B protein, RIG-B, UbcH8, Ubiquitin carrier protein L6, Ubiquitin-protein ligase L6, UBE2L6, UBCH8|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.|
|Tissue Location||Present in natural killer cells (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
The modification of proteins with ubiquitin is animportant cellular mechanism for targeting abnormal or short-livedproteins for degradation. Ubiquitination involves at least threeclasses of enzymes: ubiquitin-activating enzymes (E1s),ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases(E3s). This gene encodes a member of the E2 ubiquitin-conjugatingenzyme family. This enzyme is highly similar in primary structureto the enzyme encoded by UBE2L3 gene.
Buchwald, M., et al. Leukemia 24(8):1412-1421(2010)Serniwka, S.A., et al. Biochemistry 48(51):12169-12179(2009)van Wijk, S.J., et al. Mol. Syst. Biol. 5, 295 (2009) :Durfee, L.A., et al. J. Biol. Chem. 283(35):23895-23902(2008)Fortier, J.M., et al. J. Immunol. 176(11):6454-6463(2006)
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