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UBE2L6 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O14933
Clone Names 100517322
Additional Information
Gene ID 9246
Other Names Ubiquitin/ISG15-conjugating enzyme E2 L6, Retinoic acid-induced gene B protein, RIG-B, UbcH8, Ubiquitin carrier protein L6, Ubiquitin-protein ligase L6, UBE2L6, UBCH8
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBE2L6
Synonyms UBCH8
Function Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.
Tissue Location Present in natural killer cells (at protein level).
Research Areas
Citations (0)
citation

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Background

The modification of proteins with ubiquitin is animportant cellular mechanism for targeting abnormal or short-livedproteins for degradation. Ubiquitination involves at least threeclasses of enzymes: ubiquitin-activating enzymes (E1s),ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases(E3s). This gene encodes a member of the E2 ubiquitin-conjugatingenzyme family. This enzyme is highly similar in primary structureto the enzyme encoded by UBE2L3 gene.

References

Buchwald, M., et al. Leukemia 24(8):1412-1421(2010)Serniwka, S.A., et al. Biochemistry 48(51):12169-12179(2009)van Wijk, S.J., et al. Mol. Syst. Biol. 5, 295 (2009) :Durfee, L.A., et al. J. Biol. Chem. 283(35):23895-23902(2008)Fortier, J.M., et al. J. Immunol. 176(11):6454-6463(2006)

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$ 277.78
Cat# BP16401b
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