|Other Names||Guanylate cyclase activator 2B, Guanylate cyclase C-activating peptide 2, Guanylate cyclase C-activating peptide II, GCAP-II, Uroguanylin, UGN, GUCA2B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.|
|Tissue Location||Stomach and intestine.|
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Provided below are standard protocols that you may find useful for product applications.
Uroguanylin and guanylin (GUCA2A; MIM 139392), peptidehomologs of the bacterial heat-stable enterotoxins (e.g., the E.coli ST toxin; STa), are endogenous activators of the guanylatecyclase-2C receptor (GUCY2C; MIM 601330), which synthesizes cyclicGMP (cGMP), a key component of several intracellular signaltransduction pathways.
Yoshikawa, Y., et al. Hypertens. Res. 30(9):789-796(2007)Guo, H.F., et al. Zhonghua Xin Xue Guan Bing Za Zhi 35(3):233-236(2007)Sindic, A., et al. Kidney Int. 67(4):1420-1427(2005)Maake, C., et al. Histochem. Cell Biol. 119(1):69-76(2003)Sindice, A., et al. J. Biol. Chem. 277(20):17758-17764(2002)
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