|Other Names||Myelin transcription factor 1, MyT1, Myelin transcription factor I, MyTI, PLPB1, Proteolipid protein-binding protein, MYT1, KIAA0835, KIAA1050, MTF1, MYTI, PLPB1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0835, KIAA1050, MTF1, MYTI, PLPB1|
|Function||Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up- regulation of myelin gene transcription.|
|Tissue Location||Mostly in developing nervous system. Expressed in neural progenitors and oligodendrocyte lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes.|
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Provided below are standard protocols that you may find useful for product applications.
MYT1 is a member of a familyof neural specific, zinc finger-containing DNA-binding proteins.The protein binds to the promoter regions of proteolipid proteinsof the central nervous system and plays a role in the developingnervous system.
Choi, H.S., et al. Mol. Cell. Biol. 29(8):2168-2180(2009)Vega, A., et al. Gynecol. Oncol. 112(1):210-214(2009)Vana, A.C., et al. Glia 55(7):687-697(2007)Nielsen, J.A., et al. Mol. Cell. Neurosci. 25(1):111-123(2004)Nakajima, H., et al. J. Biol. Chem. 278(28):25277-25280(2003)
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