|Other Names||High affinity choline transporter 1, Hemicholinium-3-sensitive choline transporter, CHT, Solute carrier family 5 member 7, SLC5A7, CHT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion- dependent.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in putamen, spinal cord and medulla. Specific for cholinergic neurons|
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Provided below are standard protocols that you may find useful for product applications.
Choline is a direct precursor of acetylcholine (ACh), aneurotransmitter of the central and peripheral nervous system thatregulates a variety of autonomic, cognitive, and motor functions.SLC5A7 is a Na(+)- and Cl(-)- dependent high-affinity transporterthat mediates the uptake of choline for acetylcholine synthesis incholinergic neurons (Apparsundaram et al., 2000 [PubMed11027560]).
Harrington, A.M., et al. Cell Tissue Res. 341(1):33-48(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Neumann, S.A., et al. Biol. Psychiatry 60(10):1155-1162(2006)Iwamoto, H., et al. J. Neurosci. 26(39):9851-9859(2006)Hillier, L.W., et al. Nature 434(7034):724-731(2005)
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