|Other Names||F-box-like/WD repeat-containing protein TBL1XR1, Nuclear receptor corepressor/HDAC3 complex subunit TBLR1, TBL1-related protein 1, Transducin beta-like 1X-related protein 1, TBL1XR1, IRA1, TBLR1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.|
|Tissue Location||Widely expressed including the pituitary, hypothalamus, white and brown adipose tissue, muscle and liver|
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TBL1XR1 has sequence similaritywith members of the WD40 repeat-containing protein family. The WD40group is a large family of proteins, which appear to have aregulatory function. It is believed that the WD40 repeats mediateprotein-protein interactions and members of the family are involvedin signal transduction, RNA processing, gene regulation, vesiculartrafficking, cytoskeletal assembly and may play a role in thecontrol of cytotypic differentiation.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Rothenberg, M.E., et al. Nat. Genet. 42(4):289-291(2010)Parker, H., et al. Genes Chromosomes Cancer 47(12):1118-1125(2008)Ishii, S., et al. Proc. Natl. Acad. Sci. U.S.A. 105(11):4179-4184(2008)Li, J., et al. Nat. Cell Biol. 10(2):160-169(2008)
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