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TBL1XR1 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Primary Accession Q9BZK7
Clone Names 100528248
Additional Information
Gene ID 79718
Other Names F-box-like/WD repeat-containing protein TBL1XR1, Nuclear receptor corepressor/HDAC3 complex subunit TBLR1, TBL1-related protein 1, Transducin beta-like 1X-related protein 1, TBL1XR1, IRA1, TBLR1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TBL1XR1
Synonyms IRA1, TBLR1
Function F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.
Cellular Location Nucleus.
Tissue Location Widely expressed including the pituitary, hypothalamus, white and brown adipose tissue, muscle and liver
Research Areas
Citations (0)
citation

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Background

TBL1XR1 has sequence similaritywith members of the WD40 repeat-containing protein family. The WD40group is a large family of proteins, which appear to have aregulatory function. It is believed that the WD40 repeats mediateprotein-protein interactions and members of the family are involvedin signal transduction, RNA processing, gene regulation, vesiculartrafficking, cytoskeletal assembly and may play a role in thecontrol of cytotypic differentiation.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Rothenberg, M.E., et al. Nat. Genet. 42(4):289-291(2010)Parker, H., et al. Genes Chromosomes Cancer 47(12):1118-1125(2008)Ishii, S., et al. Proc. Natl. Acad. Sci. U.S.A. 105(11):4179-4184(2008)Li, J., et al. Nat. Cell Biol. 10(2):160-169(2008)

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$ 277.78
Cat# BP16411a
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