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RGS8 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P57771
Clone Names 100528272
Peptide ID 100528272
Additional Information
Gene ID 85397
Other Names Regulator of G-protein signaling 8, RGS8, RGS8
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RGS8
Function Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:18434541). Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling (By similarity).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:P49804}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49804}; Cytoplasmic side {ECO:0000250|UniProtKB:P49804}. Membrane {ECO:0000250|UniProtKB:P49804}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49804}; Cytoplasmic side {ECO:0000250|UniProtKB:P49804}. Perikaryon {ECO:0000250|UniProtKB:P49804}. Cell projection, dendrite {ECO:0000250|UniProtKB:P49804}. Nucleus {ECO:0000250|UniProtKB:P49804}. Note=Detected in Purkinje cell soma and dendrites. Associated with Purkinje cell membranes. Not detected in Purkinje cell nuclei. Detected in the nucleus after heterologous expression. Recruited to the cell membrane in the presence of GNAO1. {ECO:0000250|UniProtKB:P49804}
Research Areas
Citations (0)

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Background

RGS8 is a member of the regulator of G proteinsignaling (RGS) family and encodes a protein with a single RGSdomain. Regulator of G protein signaling (RGS) proteins areregulatory and structural components of G protein-coupled receptorcomplexes. They accelerate transit through the cycle of GTP bindingand hydrolysis to GDP, thereby terminating signal transduction, butparadoxically, also accelerate receptor-stimulated activation.

References

Wang, J., et al. Carcinogenesis 31(10):1755-1761(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Fujii, S., et al. Biochem. Biophys. Res. Commun. 377(1):200-204(2008)Campbell, D.B., et al. Schizophr. Res. 101 (1-3), 67-75 (2008) :Lamesch, P., et al. Genomics 89(3):307-315(2007)

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$ 80.00
Cat# BP16415a
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