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RGS8 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P57771 |
|---|---|
| Clone Names | 100528272 |
| Gene ID | 85397 |
|---|---|
| Other Names | Regulator of G-protein signaling 8, RGS8, RGS8 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RGS8 |
|---|---|
| Function | Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:18434541). Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P49804}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49804}; Cytoplasmic side {ECO:0000250|UniProtKB:P49804}. Membrane {ECO:0000250|UniProtKB:P49804}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49804}; Cytoplasmic side {ECO:0000250|UniProtKB:P49804}. Perikaryon {ECO:0000250|UniProtKB:P49804}. Cell projection, dendrite {ECO:0000250|UniProtKB:P49804}. Nucleus {ECO:0000250|UniProtKB:P49804} Note=Detected in Purkinje cell soma and dendrites. Associated with Purkinje cell membranes. Not detected in Purkinje cell nuclei. Detected in the nucleus after heterologous expression. Recruited to the cell membrane in the presence of GNAO1. {ECO:0000250|UniProtKB:P49804} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
RGS8 is a member of the regulator of G proteinsignaling (RGS) family and encodes a protein with a single RGSdomain. Regulator of G protein signaling (RGS) proteins areregulatory and structural components of G protein-coupled receptorcomplexes. They accelerate transit through the cycle of GTP bindingand hydrolysis to GDP, thereby terminating signal transduction, butparadoxically, also accelerate receptor-stimulated activation.
References
Wang, J., et al. Carcinogenesis 31(10):1755-1761(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Fujii, S., et al. Biochem. Biophys. Res. Commun. 377(1):200-204(2008)Campbell, D.B., et al. Schizophr. Res. 101 (1-3), 67-75 (2008) :Lamesch, P., et al. Genomics 89(3):307-315(2007)
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