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PKD2L1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9P0L9
Clone Names 100528273
Peptide ID 100528273
Additional Information
Gene ID 9033
Other Names Polycystic kidney disease 2-like 1 protein, Polycystin-2 homolog, Polycystin-2L1, Polycystin-L, Polycystin-L1, PKD2L1, PKD2L, PKDL, TRPP3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PKD2L1
Synonyms PKD2L, PKDL, TRPP3
Function Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.
Cellular Location Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein Endoplasmic reticulum. Note=Interaction with PKD1 or PKD1L3 is required for localization to the cell membrane
Tissue Location Expressed in adult heart, skeletal muscle, brain, spleen, testis, retina and liver. According to PubMed:9748274, expressed at high levels in fetal tissues, including kidney and liver, and down-regulated in adult tissues According to PubMed:10602361, expressed in fetal brain, but not expressed in fetal lung, liver or kidney. Isoform 4 appears to be expressed only in transformed lymphoblasts
Research Areas
Citations (0)

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PKD2L1 is a member of the polycystin proteinfamily. The encoded protein contains multiple transmembranedomains, and cytoplasmic N- and C-termini. The protein may be anintegral membrane protein involved in cell-cell/matrixinteractions. This protein functions as a calcium-regulatednonselective cation channel. Alternative splice variants have beendescribed but their full length sequences have not been determined.


Molland, K.L., et al. Biochem. J. 429(1):171-183(2010)Kawaguchi, H., et al. J. Biol. Chem. 285(23):17277-17281(2010)Li, Q., et al. J. Neurochem. 103(6):2391-2400(2007)Geng, L., et al. J. Cell. Sci. 119 (PT 7), 1383-1395 (2006) :Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)

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$ 80.00
Cat# BP16416a
Availability: In Stock
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