|Other Names||Translocon-associated protein subunit delta, TRAP-delta, Signal sequence receptor subunit delta, SSR-delta, SSR4, TRAPD|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type I membrane protein|
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SSR4, also called TRAPD, is assumed to be involved inprotein secretion. It is located in the Xq28 region, arranged in acompact head-to-head manner with the IDH3G gene. These two genesare driven by a bidirectional promoter located between them, andencode proteins involved in unrelated biochemical pathways locatedin different compartments of the cell. The nontranscribedintergenic region represents only 133 bp and is embedded in a CpGisland. The CpG island functions as a bidirectional promoter toinitiate the transcription of both functionally unrelated geneswith distinct expression patterns. SSR4 consists of six exons andis approximately 70 kb telomeric to the ALD gene. Althoughalternative splicing of exon 5 has not been detected in human SSR4,transcript variants missing the region homologous to human exon 5have been detected in both Xenopus laevis and Mus musculus.
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Wang, Z., et al. Melanoma Res. 14(2):107-114(2004)Miyazaki, K., et al. J. Biol. Chem. 279(12):11327-11335(2004)Wang, L., et al. FEBS Lett. 457(3):316-322(1999)Dodson, G., et al. Curr. Opin. Struct. Biol. 8(2):189-194(1998)
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