|Other Names||Chromodomain-helicase-DNA-binding protein 1-like, Amplified in liver cancer protein 1, CHD1L, ALC1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding.|
|Cellular Location||Nucleus. Note=Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1|
|Tissue Location||Frequently overexpressed in hepatomacellular carcinomas.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
In response to DNA strand breaks, chromatin adopts arelaxed structure due to the addition of poly(ADP-ribose) (PAR) tochromatin proteins by PARP enzymes (see PARP1; MIM 173870), andthis relaxation facilitates the repair of DNA damage. CHD1Linteracts with PAR and has a role in chromatin relaxation followingDNA damage (Ahel et al., 2009 [PubMed 19661379]).[supplied byOMIM].
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Chen, L., et al. J. Clin. Invest. 120(4):1178-1191(2010)Ahel, D., et al. Science 325(5945):1240-1243(2009)Gottschalk, A.J., et al. Proc. Natl. Acad. Sci. U.S.A. 106(33):13770-13774(2009)Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008) :
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.