|Other Names||Chromodomain-helicase-DNA-binding protein 1-like, Amplified in liver cancer protein 1, CHD1L, ALC1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding.|
|Cellular Location||Nucleus. Note=Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1|
|Tissue Location||Frequently overexpressed in hepatomacellular carcinomas.|
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In response to DNA strand breaks, chromatin adopts arelaxed structure due to the addition of poly(ADP-ribose) (PAR) tochromatin proteins by PARP enzymes (see PARP1; MIM 173870), andthis relaxation facilitates the repair of DNA damage. CHD1Linteracts with PAR and has a role in chromatin relaxation followingDNA damage (Ahel et al., 2009 [PubMed 19661379]).[supplied byOMIM].
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Chen, L., et al. J. Clin. Invest. 120(4):1178-1191(2010)Ahel, D., et al. Science 325(5945):1240-1243(2009)Gottschalk, A.J., et al. Proc. Natl. Acad. Sci. U.S.A. 106(33):13770-13774(2009)Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008) :
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