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CHD1L Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q86WJ1 |
|---|---|
| Clone Names | 100528328 |
| Gene ID | 9557 |
|---|---|
| Other Names | Chromodomain-helicase-DNA-binding protein 1-like, Amplified in liver cancer protein 1, CHD1L, ALC1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CHD1L {ECO:0000303|PubMed:34210977, ECO:0000312|HGNC:HGNC:1916} |
|---|---|
| Function | ATP-dependent chromatin remodeler that mediates chromatin- remodeling following DNA damage (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:33357431, PubMed:34486521, PubMed:34874266, PubMed:34210977). Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:34874266, PubMed:34486521). Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:34874266, PubMed:34486521). Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner (PubMed:19661379, PubMed:29220652, PubMed:29220653). Chromatin remodeling activity promotes PARP2 removal from chromatin (PubMed:33275888). |
| Cellular Location | Nucleus. Chromosome Note=Localizes at sites of DNA damage; recruited by histones H2B and H3 poly-ADP-ribosylated on 'Ser-6' and 'Ser-10', respectively (H2BS6ADPr and H3S10ADPr) by PARP1 or PARP2. |
| Tissue Location | Frequently overexpressed in hepatomacellular carcinomas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
In response to DNA strand breaks, chromatin adopts arelaxed structure due to the addition of poly(ADP-ribose) (PAR) tochromatin proteins by PARP enzymes (see PARP1; MIM 173870), andthis relaxation facilitates the repair of DNA damage. CHD1Linteracts with PAR and has a role in chromatin relaxation followingDNA damage (Ahel et al., 2009 [PubMed 19661379]).[supplied byOMIM].
References
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Chen, L., et al. J. Clin. Invest. 120(4):1178-1191(2010)Ahel, D., et al. Science 325(5945):1240-1243(2009)Gottschalk, A.J., et al. Proc. Natl. Acad. Sci. U.S.A. 106(33):13770-13774(2009)Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008) :
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