|Other Names||Mitochondrial enolase superfamily member 1, Antisense RNA to thymidylate synthase, rTS, L-fuconate dehydratase, ENOSF1, RTS, TYMSAS|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins. Catalyzes the dehydration of L-fuconate to 2-keto- 3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion (PubMed:24697329).|
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ENOSF1 was originally identified as a naturallyoccurring antisense transcript to the human thymidylate synthasegene. Alternate splice variants have been described, one of which(named rTSalpha) represents an alternate 3'UTR that iscomplementary to the 3'UTR and terminal intron of the thymidylatesynthase (TS) RNA and down-regulates TS expression. Othertranscript variants (rTSbeta and rTSgamma) do not overlap the TSlocus. The function of this gene appears to be primarily toregulate expression of the TS locus both via the antisensetranscript as well as through the encoded proteins. [provided byRefSeq].
Giusti, B., et al. Thromb. Haemost. 104(2):231-242(2010)Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010)Cross, D.S., et al. BMC Genet. 11, 51 (2010) :Giusti, B., et al. J. Med. Genet. 45(11):721-730(2008)Giusti, B., et al. Biochem. Genet. 46 (7-8), 406-423 (2008) :
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