|Other Names||BAG family molecular chaperone regulator 5, BAG-5, Bcl-2-associated athanogene 5, BAG5, KIAA0873|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.|
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Provided below are standard protocols that you may find useful for product applications.
BAG5 is a member of theBAG1-related protein family. BAG1 is an anti-apoptotic protein thatfunctions through interactions with a variety of cell apoptosis andgrowth related proteins including BCL-2, Raf-protein kinase,steroid hormone receptors, growth factor receptors and members ofthe heat shock protein 70 kDa family. This protein contains a BAGdomain near the C-terminus, which could bind and inhibit thechaperone activity of Hsc70/Hsp70. Three transcript variantsencoding two different isoforms have been found for this gene.
Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Kalia, S.K., et al. Neuron 44(6):931-945(2004)Takayama, S., et al. J. Biol. Chem. 274(2):781-786(1999)Hohfeld, J., et al. EMBO J. 16(20):6209-6216(1997)
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