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Synthetic peptide
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| Primary Accession | Q9H0H3 |
|---|---|
| Clone Names | 100603093 |
| Peptide ID | 100603093 |
| Gene ID | 64410 |
|---|---|
| Other Names | Kelch-like protein 25, Ectoderm-neural cortex protein 2, ENC-2, KLHL25, ENC2 |
| Format | Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | KLHL25 |
|---|---|
| Synonyms | ENC2 |
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E. |
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Provided below are standard protocols that you may find useful for product applications.
References
Lunetta, K.L., et al. BMC Med. Genet. 8 SUPPL 1, S13 (2007) :Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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