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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   KLHL25 Antibody (N-term) Blocking Peptide   

KLHL25 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9H0H3
Clone Names 100603093
Peptide ID 100603093
Additional Information
Gene ID 64410
Other Names Kelch-like protein 25, Ectoderm-neural cortex protein 2, ENC-2, KLHL25, ENC2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLHL25
Synonyms ENC2
Function Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.
Research Areas
Citations (0)

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Lunetta, K.L., et al. BMC Med. Genet. 8 SUPPL 1, S13 (2007) :Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)

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$ 80.00
Cat# BP16430a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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