|Other Names||Tapasin-related protein, TAPASIN-R, TAP-binding protein-like, TAP-binding protein-related protein, TAPBP-R, Tapasin-like, TAPBPL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2- microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein Endoplasmic reticulum membrane; Single-pass type I membrane protein Microsome membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Mainly found in endoplasmic reticulum but a minority is found on the cell surface (PubMed:11920573)|
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Provided below are standard protocols that you may find useful for product applications.
Tapasin, or TAPBP (MIM 601962), is a member of thevariable-constant Ig superfamily that links majorhistocompatibility complex (MHC) class I molecules to thetransporter associated with antigen processing (TAP; see MIM170260) in the endoplasmic reticulum (ER). The TAPBP gene islocated near the MHC complex on chromosome 6p21.3. TAPBPL is amember of the Ig superfamily that is localized on chromosome12p13.3, a region somewhat paralogous to the MHC.[supplied byOMIM].
Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)Lee, J.H., et al. Neurogenetics 9(2):127-138(2008)Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)Teng, M.S., et al. Eur. J. Immunol. 32(4):1059-1068(2002)
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