|Other Names||Tapasin-related protein, TAPASIN-R, TAP-binding protein-like, TAP-binding protein-related protein, TAPBP-R, Tapasin-like, TAPBPL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2- microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein Endoplasmic reticulum membrane; Single-pass type I membrane protein Microsome membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Mainly found in endoplasmic reticulum but a minority is found on the cell surface (PubMed:11920573)|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Tapasin, or TAPBP (MIM 601962), is a member of thevariable-constant Ig superfamily that links majorhistocompatibility complex (MHC) class I molecules to thetransporter associated with antigen processing (TAP; see MIM170260) in the endoplasmic reticulum (ER). The TAPBP gene islocated near the MHC complex on chromosome 6p21.3. TAPBPL is amember of the Ig superfamily that is localized on chromosome12p13.3, a region somewhat paralogous to the MHC.[supplied byOMIM].
Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)Lee, J.H., et al. Neurogenetics 9(2):127-138(2008)Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)Teng, M.S., et al. Eur. J. Immunol. 32(4):1059-1068(2002)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.