|Other Names||Centrosomal protein of 72 kDa, Cep72, CEP72, KIAA1519|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (PubMed:19536135). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806).|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Localizes to the centrosome and centrosome-surrounding particles throughout the cell cycle These particles disappear after microtubules are depolymerized using nocodazole, suggesting that CEP72-associating particles localize in a microtubule- dependent manner|
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Provided below are standard protocols that you may find useful for product applications.
CEP72 is a member of theleucine-rich-repeat (LRR) superfamily of proteins. The protein islocalized to the centrosome, a non-membraneous organelle thatfunctions as the major microtubule-organizing center in animalcells.
McGovern, D.P., et al. Nat. Genet. 42(4):332-337(2010)Briggs, F.B., et al. Genes Immun. 11(3):199-208(2010)Oshimori, N., et al. EMBO J. 28(14):2066-2076(2009)Xin, X., et al. Genome Res. 19(7):1262-1269(2009)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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