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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   CEP72 Antibody (Center) Blocking Peptide   

CEP72 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9P209
Clone Names 100603208
Peptide ID 100603208
Additional Information
Gene ID 55722
Other Names Centrosomal protein of 72 kDa, Cep72, CEP72, KIAA1519
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CEP72
Synonyms KIAA1519
Function Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (PubMed:19536135). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806).
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Localizes to the centrosome and centrosome-surrounding particles throughout the cell cycle These particles disappear after microtubules are depolymerized using nocodazole, suggesting that CEP72-associating particles localize in a microtubule- dependent manner
Research Areas
Citations (0)

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Background

CEP72 is a member of theleucine-rich-repeat (LRR) superfamily of proteins. The protein islocalized to the centrosome, a non-membraneous organelle thatfunctions as the major microtubule-organizing center in animalcells.

References

McGovern, D.P., et al. Nat. Genet. 42(4):332-337(2010)Briggs, F.B., et al. Genes Immun. 11(3):199-208(2010)Oshimori, N., et al. EMBO J. 28(14):2066-2076(2009)Xin, X., et al. Genome Res. 19(7):1262-1269(2009)Olsen, J.V., et al. Cell 127(3):635-648(2006)

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$ 80.00
Cat# BP16441c
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