|Other Names||G-protein coupled receptor family C group 5 member B, A-69G121, Retinoic acid-induced gene 2 protein, RAIG-2, GPRC5B, RAIG2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.|
|Cellular Location||Cell membrane; Multi-pass membrane protein Cytoplasmic vesicle membrane; Multi- pass membrane protein Note=Localized in the plasma membrane and perinuclear vesicles|
|Tissue Location||Expression is high in kidney, pancreas, and testis, medium in brain, heart, prostate, small intestine, and spleen, low in liver, placenta, skeletal muscle, colon, ovary, and thymus, and not detectable in lung and peripheral leukocyte According to PubMed:10945465, highly expressed in most brain areas examined, with the highest levels observed in corpus callosum, caudate nucleus, putamen, substantia nigra, thalamus, hippocampus, and spinal chord as well as in dorsal root ganglia (DRG). In the periphery, expression levels are relatively low, compared to the CNS, with the strongest expression detected in pancreas, testis, uterus, and stomach.|
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Provided below are standard protocols that you may find useful for product applications.
GPRC5B is a member of the type 3G protein-coupled receptor family. Members of this superfamily arecharacterized by a signature 7-transmembrane domain motif. Thespecific function of this protein is unknown; however, this proteinmay mediate the cellular effects of retinoic acid on the G proteinsignal transduction cascade.
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :Robbins, M.J., et al. Genomics 67(1):8-18(2000)Brauner-Osborne, H., et al. Genomics 65(2):121-128(2000)Loftus, B.J., et al. Genomics 60(3):295-308(1999)
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