|Other Names||Growth hormone variant, GH-V, Growth hormone 2, Placenta-specific growth hormone, GH2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.|
|Tissue Location||Expressed in the placenta.|
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The protein encoded by this gene is a member of thesomatotropin/prolactin family of hormones which play an importantrole in growth control. The gene, along with four other relatedgenes, is located at the growth hormone locus on chromosome 17where they are interspersed in the same transcriptionalorientation; an arrangement which is thought to have evolved by aseries of gene duplications. The five genes share a remarkably highdegree of sequence identity. Alternative splicing generatesadditional isoforms of each of the five growth hormones, leading tofurther diversity and potential for specialization. As in the caseof its pituitary counterpart, growth hormone 1, the predominantisoform of this particular family member shows similar somatogenicactivity, with reduced lactogenic activity. Mutations in this genelead to placental growth hormone/lactogen deficiency. [provided byRefSeq].
McElholm, A.R., et al. Gastroenterology 139(1):204-212(2010)de Jesus Romero-Prado, M.M., et al. Gene 452(1):7-15(2010)Christiansen, M. Prenat. Diagn. 29(13):1249-1255(2009)Zeck, W., et al. Pediatr. Res. 63(4):353-357(2008)Mittal, P., et al. J. Matern. Fetal. Neonatal. Med. 20(9):651-659(2007)
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