|Other Names||Homeobox protein Hox-A13, Homeobox protein Hox-1J, HOXA13, HOX1J|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior- posterior axis.|
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Provided below are standard protocols that you may find useful for product applications.
In vertebrates, the genes encoding the class oftranscription factors called homeobox genes are found in clustersnamed A, B, C, and D on four separate chromosomes. Expression ofthese proteins is spatially and temporally regulated duringembryonic development. This gene is part of the A cluster onchromosome 7 and encodes a DNA-binding transcription factor whichmay regulate gene expression, morphogenesis, and differentiation.Expansion of a polyalanine tract in the encoded protein can causehand-foot-uterus syndrome, also known as hand-foot-genitalsyndrome.
Jorgensen, E.M., et al. Fertil. Steril. 94(4):1235-1238(2010)Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)Gu, Z.D., et al. Cancer Res. 69(12):4969-4973(2009)Connell, K.A., et al. Menopause 16(3):529-533(2009)Yan, W.P., et al. Zhonghua Wei Chang Wai Ke Za Zhi 12(1):20-23(2009)
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