|Other Names||Speedy protein C, Rapid inducer of G2/M progression in oocytes C, RINGO C, hSpy/Ringo C, SPDYC (HGNC:32681)|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for the correct localization of the active form of Aurora B in prometaphase.|
|Cellular Location||Cytoplasm. Note=Colocalizes with tubulin gamma during interphase. During mitosis, enriched at the spindle poles and the midbody during telophase|
|Tissue Location||Expressed in a variety of tissues including bone marrow, kidney, small intestine, liver, placenta and testis|
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Provided below are standard protocols that you may find useful for product applications.
SPDYC promotes progression through the cell cycle via binding and activation of CDK1 and CDK2.
Cheng, A., et al. Cell Cycle 7(19):3037-3047(2008)Cheng, A., et al. Cell Cycle 4(1):155-165(2005)
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