|Other Names||Centromere/kinetochore protein zw10 homolog, ZW10|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241).|
|Cellular Location||Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle Note=Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm (PubMed:15029241). In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone (PubMed:11590237).|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that is one of many involvedin mechanisms to ensure proper chromosome segregation during celldivision. The encoded protein binds to centromeres during theprophase, metaphase, and early anaphase cell division stages and tokinetochore microtubules during metaphase.
Chan, Y.W., et al. J. Cell Biol. 185(5):859-874(2009)Aoki, T., et al. Mol. Biol. Cell 20(11):2639-2649(2009)Inoue, M., et al. Genes Cells 13(8):905-914(2008)Famulski, J.K., et al. J. Cell Biol. 180(3):507-520(2008)Famulski, J.K., et al. Curr. Biol. 17(24):2143-2149(2007)
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