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ZW10 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O43264
Clone Names 100528009
Peptide ID 100528009
Additional Information
Gene ID 9183
Other Names Centromere/kinetochore protein zw10 homolog, ZW10
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZW10
Function Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241).
Cellular Location Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle Note=Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm (PubMed:15029241). In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone (PubMed:11590237).
Tissue Location Widely expressed.
Research Areas
Citations (0)

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This gene encodes a protein that is one of many involvedin mechanisms to ensure proper chromosome segregation during celldivision. The encoded protein binds to centromeres during theprophase, metaphase, and early anaphase cell division stages and tokinetochore microtubules during metaphase.


Chan, Y.W., et al. J. Cell Biol. 185(5):859-874(2009)Aoki, T., et al. Mol. Biol. Cell 20(11):2639-2649(2009)Inoue, M., et al. Genes Cells 13(8):905-914(2008)Famulski, J.K., et al. J. Cell Biol. 180(3):507-520(2008)Famulski, J.K., et al. Curr. Biol. 17(24):2143-2149(2007)

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$ 80.00
Cat# BP16473a
Availability: In Stock
Bulk Size
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