|Other Names||ETS domain-containing protein Elk-3, ETS-related protein ERP, ETS-related protein NET, Serum response factor accessory protein 2, SAP-2, SRF accessory protein 2, ELK3, NET, SAP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of theETS-domain transcription factor family and the ternary complexfactor (TCF) subfamily. Proteins in this subfamily regulatetranscription when recruited by serum response factor to bind toserum response elements. This protein is activated bysignal-induced phosphorylation; studies in rodents suggest that itis a transcriptional inhibitor in the absence of Ras, but activatestranscription when Ras is present.
Serchov, T., et al. J. Biol. Chem. 285(28):21223-21232(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Li, B., et al. Tohoku J. Exp. Med. 216(2):139-147(2008)Wasylyk, C., et al. Cancer Res. 68(5):1275-1283(2008)Wu, C., et al. Proteomics 7(11):1775-1785(2007)
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