|Other Names||Krueppel-like factor 12, Transcriptional repressor AP-2rep, KLF12, AP2REP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.|
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Activator protein-2 alpha (AP-2 alpha) is adevelopmentally-regulated transcription factor and importantregulator of gene expression during vertebrate development andcarcinogenesis. The protein encoded by this gene is a member of theKruppel-like zinc finger protein family and can repress expressionof the AP-2 alpha gene by binding to a specific site in the AP-2alpha gene promoter. Repression by the encoded protein requiresbinding with a corepressor, CtBP1. Two transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Eyre, S., et al. Ann. Rheum. Dis. 69(7):1407-1408(2010)Wieczorek, S., et al. J. Mol. Med. 88(4):413-421(2010)Petersen, G.M., et al. Nat. Genet. 42(3):224-228(2010)Nakamura, Y., et al. Int. J. Cancer 125(8):1859-1867(2009)
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