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ZAR1 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q86SH2
Clone Names 100422187
Additional Information
Gene ID 326340
Other Names Zygote arrest protein 1, Oocyte-specific maternal effect factor, ZAR1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZAR1 {ECO:0000303|PubMed:12539046, ECO:0000312|HGNC:HGNC:20436}
Function mRNA-binding protein that mediates formation of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes. MARDO assembly around mitochondria is directed by an increase in mitochondrial membrane potential during oocyte growth. Promotes formation of MARDO phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to maternal mRNAs. Binds to the 3'-UTR of maternal mRNAs. Maternal mRNAs stored in the MARDO are translationally repressed. Essential for female fertility and oocyte-to-embryo transition by coordinating maternal mRNA storage, translation and degradation.
Cellular Location Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000250|UniProtKB:Q80SU3}. Cytoplasm {ECO:0000250|UniProtKB:Q80SU3}. Note=Specifically localizes to MARDO (mitochondria-associated ribonucleoprotein domain), a mitochondria- associated membraneless compartment that stores mRNAs in oocytes {ECO:0000250|UniProtKB:Q80SU3}
Tissue Location Ovary and testis..
Research Areas
Citations (0)
citation

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Background

The female gamete, the oocyte, serves the distinct purposeof transmitting the maternal genome and other maternal factorscritical for postovulation events. Oocytes have diverse functionsin ovarian folliculogenesis, fertilization, and embryogenesis. ZAR1is an oocyte-specific gene that appears to function at theoocyte-to-gamete transition (Wu et al., 2003 [PubMed12539046]).

References

Shinojima, Y., et al. J. Dermatol. Sci. 59(2):98-106(2010)Uzbekova, S., et al. Reprod. Biol. Endocrinol. 4, 12 (2006) :Wu, X., et al. Biol. Reprod. 69(3):861-867(2003)Wu, X., et al. Nat. Genet. 33(2):187-191(2003)

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$ 277.78
Cat# BP16486c
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