|Other Names||Collagen type IV alpha-3-binding protein, Ceramide transfer protein, hCERT, Goodpasture antigen-binding protein, GPBP, START domain-containing protein 11, StARD11, StAR-related lipid transfer protein 11, COL4A3BP, CERT, STARD11|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.|
|Cellular Location||Cytoplasm. Golgi apparatus. Endoplasmic reticulum Note=Preferentially localized to the Golgi apparatus|
|Tissue Location||Widely expressed.|
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This gene encodes a kinase that specificallyphosphorylates the N-terminal region of the non-collagenous domainof the alpha 3 chain of type IV collagen, known as the Goodpastureantigen. Goodpasture disease is the result of an autoimmuneresponse directed at this antigen. One isoform of this protein isalso involved in ceramide intracellular transport. Three transcriptvariants encoding different isoforms have been found for this gene.
Miralem, T., et al. J. Biol. Chem. 285(17):12551-12558(2010)Kudo, N., et al. J. Mol. Biol. 396(2):245-251(2010)Lowe, J.K., et al. PLoS Genet. 5 (2), E1000365 (2009) :Tomishige, N., et al. Mol. Biol. Cell 20(1):348-357(2009)Asero, R., et al. Int. Arch. Allergy Immunol. 150(3):271-277(2009)
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