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MYF5 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P13349
Clone Names 100528202
Peptide ID 100528202
Additional Information
Other Names Myogenic factor 5, Myf-5, Class C basic helix-loop-helix protein 2, bHLHc2, MYF5, BHLHC2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MYF5
Synonyms BHLHC2
Function Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.
Cellular Location Nucleus. EMBL; X14894; CAA33025.1; -; mRNA EMBL; CH471054; EAW97368.1; -; Genomic_DNA EMBL; BC069373; AAH69373.1; -; mRNA EMBL; U27313; AAA69824.1; -; Genomic_DNA CCDS; CCDS9020.1; - PIR; S04105; S04105 RefSeq; NP_005584.2; NM_005593.2 UniGene; Hs.178023; - ProteinModelPortal; P13349; - SMR; P13349; - BioGrid; 110702; 4 IntAct; P13349; 26 STRING; 9606.ENSP00000228644; - iPTMnet; P13349; - PhosphoSitePlus; P13349; - BioMuta; MYF5; - DMDM; 215274028; - PaxDb; P13349; - PRIDE; P13349; - ProteomicsDB; 52906; - Ensembl; ENST00000228644; ENSP00000228644; ENSG00000111049 GeneID; 4617; - KEGG; hsa:4617; - UCSC; uc001szg.3; human CTD; 4617; - DisGeNET; 4617; - EuPathDB; HostDB:ENSG00000111049.3; - GeneCards; MYF5; - HGNC; HGNC:7565; MYF5 HPA; HPA041691; - MIM; 159990; gene neXtProt; NX_P13349; - OpenTargets; ENSG00000111049; - PharmGKB; PA31363; - eggNOG; KOG3960; Eukaryota eggNOG; ENOG4111SED; LUCA GeneTree; ENSGT00530000063004; - HOGENOM; HOG000234800; - HOVERGEN; HBG006429; - InParanoid; P13349; - KO; K18484; - OMA; SFDSVYC; - OrthoDB; EOG091G0GKD; - PhylomeDB; P13349; - TreeFam; TF316344; - Reactome; R-HSA-375170; CDO in myogenesis SignaLink; P13349; - SIGNOR; P13349; - GenomeRNAi; 4617; - PRO; PR:P13349; - Proteomes; UP000005640; Chromosome 12 Bgee; ENSG00000111049; - CleanEx; HS_MYF5; - Genevisible; P13349; HS GO; GO:0005654; C:nucleoplasm; IDA:HPA GO; GO:0005634; C:nucleus; IBA:GO_Central GO; GO:0090575; C:RNA polymerase II transcription factor complex; ISS:BHF-UCL GO; GO:0046982; F:protein heterodimerization activity; ISS:BHF-UCL GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IBA:GO_Central GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISA:NTNU_SB GO; GO:0003705; F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; TAS:ProtInc GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central GO; GO:0043010; P:camera-type eye development; IEA:Ensembl GO; GO:0001502; P:cartilage condensation; IEA:Ensembl GO; GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Ensembl GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl GO; GO:0042693; P:muscle cell fate commitment; ISS:BHF-UCL GO; GO:0007517; P:muscle organ development; TAS:ProtInc GO; GO:0060415; P:muscle tissue morphogenesis; IEA:Ensembl GO; GO:0001503; P:ossification; IEA:Ensembl GO; GO:0051149; P:positive regulation of muscle cell differentiation; TAS:Reactome GO; GO:0045663; P:positive regulation of myoblast differentiation; IBA:GO_Central GO; GO:1901741; P:positive regulation of myoblast fusion; IBA:GO_Central GO; GO:0048743; P:positive regulation of skeletal muscle fiber development; IBA:GO_Central GO; GO:0001952; P:regulation of cell-matrix adhesion; IEA:Ensembl GO; GO:0006357; P:regulation of transcription by RNA polymerase II; TAS:ProtInc GO; GO:0035914; P:skeletal muscle cell differentiation; IBA:GO_Central GO; GO:0007519; P:skeletal muscle tissue development; TAS:ProtInc GO; GO:0001756; P:somitogenesis; IEA:Ensembl CDD; cd00083; HLH; 1 Gene3D; 4.10.280.10; -; 1 InterPro; IPR002546; Basic InterPro; IPR011598; bHLH_dom InterPro; IPR036638; HLH_DNA-bd_sf InterPro; IPR022032; Myf5 Pfam; PF01586; Basic; 1 Pfam; PF00010; HLH; 1 Pfam; PF12232; Myf5; 1 SMART; SM00520; BASIC; 1 SMART; SM00353; HLH; 1 SUPFAM; SSF47459; SSF47459; 1 PROSITE; PS50888; BHLH; 1 2: Evidence at transcript level; Activator; Complete proteome; Developmental protein; Differentiation; DNA-binding; Myogenesis; Nucleus; Reference proteome; Transcription; Transcription regulation CHAIN 1 255 Myogenic factor 5 /FTId=PRO_0000127344 DOMAIN 83 134 bHLH. {ECO:0000255|PROSITE- ProRule:PRU00981} CONFLICT 241 241 A -> R (in Ref. 1; CAA33025) SEQUENCE 255 AA; 28296 MW; 62F00454C729BE66 CRC64; MDVMDGCQFS PSEYFYDGSC IPSPEGEFGD EFVPRVAAFG AHKAELQGSD EDEHVRAPTG HHQAGHCLMW ACKACKRKST TMDRRKAATM RERRRLKKVN QAFETLKRCT TTNPNQRLPK VEILRNAIRY IESLQELLRE QVENYYSLPG QSCSEPTSPT SNCSDGMPEC NSPVWSRKSS TFDSIYCPDV SNVYATDKNS LSSLDCLSNI VDRITSSEQP GLPLQDLASL SPVASTDSQP ATPGASSSRL IYHVL
Research Areas
Citations (0)

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Background

MYF5 is involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.

References

Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)Venza, M., et al. J. Oral Pathol. Med. 38(1):18-23(2009)Ansseau, E., et al. PLoS ONE 4 (10), E7482 (2009) :Kosek, D.J., et al. J. Appl. Physiol. 101(2):531-544(2006)Summerbell, D., et al. Mech. Dev. 117 (1-2), 331-335 (2002) :

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$ 80.00
Cat# BP16491a
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