|Other Names||AP-3 complex subunit sigma-2, AP-3 complex subunit sigma-3B, Adaptor-related protein complex 3 subunit sigma-2, Sigma-3B-adaptin, Sigma3B-adaptin, Sigma-adaptin 3b, AP3S2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.|
|Cellular Location||Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.|
|Tissue Location||Present in all adult tissues examined.|
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Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.
Lefrancois, S., et al. Dev. Cell 7(4):619-625(2004)Nie, Z., et al. Dev. Cell 5(3):513-521(2003)Falcon-Perez, J.M., et al. J. Biol. Chem. 277(31):28191-28199(2002)Rous, B.A., et al. Mol. Biol. Cell 13(3):1071-1082(2002)Dell'Angelica, E.C., et al. J. Biol. Chem. 272(24):15078-15084(1997)
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