PGRMC2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O15173 |
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Other Accession | http://www.uniprot.org/uniprot/O15173==O15173@@http://www.ncbi.nlm.nih.gov/protein/NP_006311.1==NP_0 |
Clone Names | 100603131 |
Gene ID | 10424 |
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Other Names | Membrane-associated progesterone receptor component 2, Progesterone membrane-binding protein, Steroid receptor protein DG6, PGRMC2, DG6, PMBP |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PGRMC2 (HGNC:16089) |
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Function | Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity). Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073). In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity). |
Cellular Location | Membrane; Single- pass membrane protein. Nucleus envelope. Endoplasmic reticulum. Secreted |
Tissue Location | Expressed by endometrial glands and stroma (at protein level) (PubMed:23793472). Detected in urine (at protein level) (PubMed:37453717). |
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Provided below are standard protocols that you may find useful for product applications.
Background
PGRMC2 is receptor for steroids (Potential).
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