|Other Names||Vacuolar protein sorting-associated protein 11 homolog, hVPS11, RING finger protein 108, VPS11, RNF108|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes.|
|Cellular Location||Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle|
|Tissue Location||Ubiquitous. Expression was highest in heart and low in lung|
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Vesicle mediated protein sorting plays an important rolein segregation of intracellular molecules into distinct organelles.Genetic studies in yeast have identified more than 40 vacuolarprotein sorting (VPS) genes involved in vesicle transport tovacuoles. This gene encodes the human homolog of yeast class CVps11 protein. The mammalian class C Vps proteins are predominantlyassociated with late endosomes/lysosomes, and like their yeastcounterparts, may mediate vesicle trafficking steps in theendosome/lysosome pathway.
Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Zhu, G.D., et al. Mol. Biol. Cell 20(4):1223-1240(2009)Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)Lehner, B., et al. Genome Res. 14(7):1315-1323(2004)
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