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VPS11 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9H270
Clone Names 100603035
Peptide ID 100603035
Additional Information
Gene ID 55823
Other Names Vacuolar protein sorting-associated protein 11 homolog, hVPS11, RING finger protein 108, VPS11, RNF108
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name VPS11
Synonyms RNF108
Function Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995).
Cellular Location Endosome. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side Lysosome membrane; Peripheral membrane protein; Cytoplasmic side Early endosome {ECO:0000269|PubMed:21148287, ECO:0000305} Cytoplasmic vesicle. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle, clathrin-coated vesicle
Tissue Location Ubiquitous. Expression was highest in heart and low in lung
Research Areas
Citations (0)

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Background

Vesicle mediated protein sorting plays an important rolein segregation of intracellular molecules into distinct organelles.Genetic studies in yeast have identified more than 40 vacuolarprotein sorting (VPS) genes involved in vesicle transport tovacuoles. This gene encodes the human homolog of yeast class CVps11 protein. The mammalian class C Vps proteins are predominantlyassociated with late endosomes/lysosomes, and like their yeastcounterparts, may mediate vesicle trafficking steps in theendosome/lysosome pathway.

References

Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Zhu, G.D., et al. Mol. Biol. Cell 20(4):1223-1240(2009)Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)Lehner, B., et al. Genome Res. 14(7):1315-1323(2004)

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$ 80.00
Cat# BP16504b
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