|Other Names||PHD finger protein 21A, BHC80a, BRAF35-HDAC complex protein BHC80, PHF21A, BHC80, KIAA1696|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.|
|Tissue Location||Highly expressed in brain. Expressed at much lower level in other tissues.|
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The PHF21A gene encodes BHC80, a component of a BRAF35(MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex(BHC) that mediates repression of neuron-specific genes through thecis-regulatory element known as repressor element-1 (RE1) or neuralrestrictive silencer (NRS) (Hakimi et al., 2002 [PubMed12032298]).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Klajn, A., et al. J. Neurosci. 29(19):6296-6307(2009)Hailesellasse Sene, K., et al. BMC Genomics 8, 85 (2007) :Shi, Y.J., et al. Mol. Cell 19(6):857-864(2005)Iwase, S., et al. Biochem. Biophys. Res. Commun. 322(2):601-608(2004)
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