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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   CAB39 Antibody (N-term) Blocking Peptide   

CAB39 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9Y376
Clone Names 61228134
Peptide ID 61228134
Additional Information
Gene ID 51719
Other Names Calcium-binding protein 39, MO25alpha, Protein Mo25, CAB39, MO25
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1650a was selected from the N-term region of human CAB39. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CAB39
Synonyms MO25
Function Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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CAB39 together with the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase, forms a regulatory complex capable of stimulating the activity of the LKB1 tumor suppressor protein kinase. The latter is mutated in the inherited Peutz-Jeghers cancer syndrome (PJS). CAB39 binds directly to a conserved Trp-Glu-Phe sequence at the STRAD alpha C terminus, markedly enhancing binding of STRAD alpha to LKB1 and increasing LKB1 catalytic activity. Skeletal muscle contraction results in the phosphorylation and activation of the AMP-activated protein kinase (AMPK) by an upstream kinase (AMPKK). The LKB1-STE-related adaptor (STRAD)-CAB39 complex is the major AMPKK in skeletal muscle; however, LKB1-STRAD-CAB39 activity is not increased by muscle contraction. This relationship suggests that phosphorylation of AMPK by LKB1-STRAD-CAB39 during skeletal muscle contraction may be regulated by allosteric mechanisms.


Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).Lai, C.H., et al., Genome Res. 10(5):703-713 (2000).

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$ 80.00
Cat# BP1650a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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