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ACTL7B Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y614 |
|---|---|
| Clone Names | 100603210 |
| Gene ID | 10880 |
|---|---|
| Other Names | Actin-like protein 7B, Actin-like-7-beta, ACTL7B |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ACTL7B |
|---|---|
| Cellular Location | Cytoplasm, cytoskeleton. |
| Tissue Location | Detected only in the testis and, to a lesser extent, in the prostate. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of a familyof actin-related proteins (ARPs) which share significant amino acidsequence identity to conventional actins. Both actins and ARPs havean actin fold, which is an ATP-binding cleft, as a common feature.The ARPs are involved in diverse cellular processes, includingvesicular transport, spindle orientation, nuclear migration andchromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A,are intronless, and are located approximately 4 kb apart in ahead-to-head orientation within the familial dysautonomia candidateregion on 9q31. Based on mutational analysis of the ACTL7B gene inpatients with this disorder, it was concluded that it is unlikelyto be involved in the pathogenesis of dysautonomia. Unlike ACTL7A,the ACTL7B gene is expressed predominantly in the testis, however,its exact function is not known.
References
Humphray, S.J., et al. Nature 429(6990):369-374(2004)Hisano, M., et al. Nucleic Acids Res. 31(16):4797-4804(2003)Chadwick, B.P., et al. Genomics 58(3):302-309(1999)Schafer, D.A., et al. Annu. Rev. Cell Dev. Biol. 15, 341-363 (1999) :
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