|Other Names||Actin-like protein 7B, Actin-like-7-beta, ACTL7B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cytoplasm, cytoskeleton.|
|Tissue Location||Detected only in the testis and, to a lesser extent, in the prostate.|
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The protein encoded by this gene is a member of a familyof actin-related proteins (ARPs) which share significant amino acidsequence identity to conventional actins. Both actins and ARPs havean actin fold, which is an ATP-binding cleft, as a common feature.The ARPs are involved in diverse cellular processes, includingvesicular transport, spindle orientation, nuclear migration andchromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A,are intronless, and are located approximately 4 kb apart in ahead-to-head orientation within the familial dysautonomia candidateregion on 9q31. Based on mutational analysis of the ACTL7B gene inpatients with this disorder, it was concluded that it is unlikelyto be involved in the pathogenesis of dysautonomia. Unlike ACTL7A,the ACTL7B gene is expressed predominantly in the testis, however,its exact function is not known.
Humphray, S.J., et al. Nature 429(6990):369-374(2004)Hisano, M., et al. Nucleic Acids Res. 31(16):4797-4804(2003)Chadwick, B.P., et al. Genomics 58(3):302-309(1999)Schafer, D.A., et al. Annu. Rev. Cell Dev. Biol. 15, 341-363 (1999) :
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