|Other Names||Acid-sensing ion channel 4, ASIC4, Amiloride-sensitive cation channel 4, Amiloride-sensitive cation channel 4, pituitary, ASIC4, ACCN4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in pituitary gland. Weakly expressed in brain, vestibular system and organ of Corti|
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This gene belongs to the superfamily of acid-sensing ionchannels, which are proton-gated, amiloride-sensitive sodiumchannels. These channels have been implicated in synaptictransmission, pain perception as well as mechanoperception. Thisgene is predominantly expressed in the pituitary gland, and wasconsidered a candidate for paroxysmal dystonic choreoathetosis(PDC), a movement disorder, however, no correlation was foundbetween mutations in this gene and PDC. Alternative splicing atthis locus results in two transcript variants encoding differentisoforms.
Donier, E., et al. Eur. J. Neurosci. 28(1):74-86(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Hillier, L.W., et al. Nature 434(7034):724-731(2005)Grunder, S., et al. Eur. J. Hum. Genet. 9(9):672-676(2001)Grunder, S., et al. Neuroreport 11(8):1607-1611(2000)
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