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NKIRAS2 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9NYR9
Clone Names 100603270
Peptide ID 100603270
Additional Information
Gene ID 28511
Other Names NF-kappa-B inhibitor-interacting Ras-like protein 2, I-kappa-B-interacting Ras-like protein 2, Kappa B-Ras protein 2, KappaB-Ras2, NKIRAS2, KBRAS2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NKIRAS2
Synonyms KBRAS2
Function Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF- kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).
Cellular Location Cytoplasm.
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Background

Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP-and GDP-bound forms block phosphorylation of NFKBIB (By similarity).

References

Tago, K., et al. J. Biol. Chem. 285(40):30622-30633(2010)Dieguez-Gonzalez, R., et al. Ann. Rheum. Dis. 68(4):579-583(2009)Fenwick, C., et al. Science 287(5454):869-873(2000)

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$ 80.00
Cat# BP16523c
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