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DND1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8IYX4 |
|---|---|
| Clone Names | 100603298 |
| Gene ID | 373863 |
|---|---|
| Other Names | Dead end protein homolog 1, RNA-binding motif, single-stranded-interacting protein 4, DND1, RBMS4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DND1 |
|---|---|
| Synonyms | RBMS4 |
| Function | RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence- specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity). |
| Cellular Location | Nucleus. Cytoplasm. Note=Perinuclear germ granules, also called germ plasm or chromatoid body. Colocalizes in perinuclear sites with APOBEC3 (By similarity). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that binds tomicroRNA-targeting sequences of mRNAs, inhibiting microRNA-mediatedrepression. Reduced expression of this gene has been implicated intongue squamous cell carcinoma. Two pseudogenes of this gene arelocated on the long arm of chromosome 17.
References
Liu, X., et al. FEBS Lett. 584(18):4115-4120(2010)Sijmons, R.H., et al. Fam. Cancer 9(3):439-442(2010)Kedde, M., et al. Cell Cycle 7(7):899-903(2008)Linger, R., et al. Genes Chromosomes Cancer 47(3):247-252(2008)Ketting, R.F. Cell 131(7):1226-1227(2007)
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