|Other Names||Dead end protein homolog 1, RNA-binding motif, single-stranded-interacting protein 4, DND1, RBMS4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Note=Perinuclear germ granules, also called germ plasm or chromatoid body. Colocalizes in perinuclear sites with APOBEC3 (By similarity).|
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This gene encodes a protein that binds tomicroRNA-targeting sequences of mRNAs, inhibiting microRNA-mediatedrepression. Reduced expression of this gene has been implicated intongue squamous cell carcinoma. Two pseudogenes of this gene arelocated on the long arm of chromosome 17.
Liu, X., et al. FEBS Lett. 584(18):4115-4120(2010)Sijmons, R.H., et al. Fam. Cancer 9(3):439-442(2010)Kedde, M., et al. Cell Cycle 7(7):899-903(2008)Linger, R., et al. Genes Chromosomes Cancer 47(3):247-252(2008)Ketting, R.F. Cell 131(7):1226-1227(2007)
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