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DND1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8IYX4
Clone Names 100603298
Peptide ID 100603298
Additional Information
Other Names Dead end protein homolog 1, RNA-binding motif, single-stranded-interacting protein 4, DND1, RBMS4
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DND1
Synonyms RBMS4
Function RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity).
Cellular Location Nucleus. Cytoplasm. Note=Perinuclear germ granules, also called germ plasm or chromatoid body. Colocalizes in perinuclear sites with APOBEC3 (By similarity). EMBL; AY321065; AAQ63635.1; -; mRNA EMBL; BC033496; AAH33496.1; -; mRNA CCDS; CCDS4236.1; - RefSeq; NP_919225.1; NM_194249.2 UniGene; Hs.591262; - ProteinModelPortal; Q8IYX4; - SMR; Q8IYX4; - BioGrid; 131887; 10 IntAct; Q8IYX4; 1 STRING; 9606.ENSP00000445366; - iPTMnet; Q8IYX4; - PhosphoSitePlus; Q8IYX4; - BioMuta; DND1; - DMDM; 60389799; - EPD; Q8IYX4; - PaxDb; Q8IYX4; - PeptideAtlas; Q8IYX4; - PRIDE; Q8IYX4; - ProteomicsDB; 71258; - DNASU; 373863; - Ensembl; ENST00000542735; ENSP00000445366; ENSG00000256453 GeneID; 373863; - KEGG; hsa:373863; - UCSC; uc003lgt.4; human CTD; 373863; - DisGeNET; 373863; - EuPathDB; HostDB:ENSG00000256453.1; - GeneCards; DND1; - HGNC; HGNC:23799; DND1 MIM; 609385; gene neXtProt; NX_Q8IYX4; - OpenTargets; ENSG00000256453; - PharmGKB; PA134931157; - eggNOG; ENOG410IUE0; Eukaryota eggNOG; ENOG410YAVC; LUCA GeneTree; ENSGT00550000074366; - HOGENOM; HOG000112240; - HOVERGEN; HBG051370; - InParanoid; Q8IYX4; - OMA; MQSKREC; - OrthoDB; EOG091G0EUB; - PhylomeDB; Q8IYX4; - TreeFam; TF314932; - GenomeRNAi; 373863; - PRO; PR:Q8IYX4; - Proteomes; UP000005640; Chromosome 5 Bgee; ENSG00000256453; - CleanEx; HS_DND1; - Genevisible; Q8IYX4; HS GO; GO:0005737; C:cytoplasm; IDA:UniProtKB GO; GO:0005634; C:nucleus; IDA:UniProtKB GO; GO:0017091; F:AU-rich element binding; IDA:UniProtKB GO; GO:0007281; P:germ cell development; IEA:Ensembl GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW GO; GO:0060965; P:negative regulation of gene silencing by miRNA; IDA:UniProtKB CDD; cd12487; RRM1_DND1; 1 Gene3D;; -; 2 InterPro; IPR034414; DND1_RRM1 InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf InterPro; IPR035979; RBD_domain_sf InterPro; IPR000504; RRM_dom Pfam; PF00076; RRM_1; 1 SMART; SM00360; RRM; 2 SUPFAM; SSF54928; SSF54928; 1 PROSITE; PS50102; RRM; 1 1: Evidence at protein level; Complete proteome; Cytoplasm; Developmental protein; Nucleus; Reference proteome; Repeat; RNA-binding CHAIN 1 353 Dead end protein homolog 1 /FTId=PRO_0000081568 DOMAIN 58 136 RRM 1. {ECO:0000255|PROSITE- ProRule:PRU00176} DOMAIN 140 213 RRM 2. {ECO:0000255|PROSITE- ProRule:PRU00176} SEQUENCE 353 AA; 38687 MW; 15014AA66BFD4F0F CRC64; MQSKRDCELW CERVNPENKA ALEAWVRETG IRLVQVNGQR KYGGPPPGWV GSPPPAGSEV FIGRLPQDVY EHQLIPLFQR VGRLYEFRLM MTFSGLNRGF AYARYSSRRG AQAAIATLHN HPLRPSCPLL VCRSTEKCEL SVDGLPPNLT RSALLLALQP LGPGLQEARL LPSPGPAPGQ IALLKFSSHR AAAMAKKALV EGQSHLCGEQ VAVEWLKPDL KQRLRQQLVG PFLRSPQPEG SQLALARDKL GFQGARATLQ LLCQRMKLGS PVFLTKCLGI GPAGWHRFWY QVVIPGHPVP FSGLIWVVLT LDGRDGHEVA KDAVSVRLLQ ALSESGANLL WSAGAEAGTM VKQ
Research Areas
Citations (0)

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This gene encodes a protein that binds tomicroRNA-targeting sequences of mRNAs, inhibiting microRNA-mediatedrepression. Reduced expression of this gene has been implicated intongue squamous cell carcinoma. Two pseudogenes of this gene arelocated on the long arm of chromosome 17.


Liu, X., et al. FEBS Lett. 584(18):4115-4120(2010)Sijmons, R.H., et al. Fam. Cancer 9(3):439-442(2010)Kedde, M., et al. Cell Cycle 7(7):899-903(2008)Linger, R., et al. Genes Chromosomes Cancer 47(3):247-252(2008)Ketting, R.F. Cell 131(7):1226-1227(2007)

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$ 80.00
Cat# BP16527c
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