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ISL2 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q96A47
Clone Names 100603300
Peptide ID 100603300
Additional Information
Other Names Insulin gene enhancer protein ISL-2, Islet-2, ISL2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ISL2
Function Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108} EMBL; AK001022; BAG50849.1; -; mRNA EMBL; CH471136; EAW99220.1; -; Genomic_DNA EMBL; BC011967; AAH11967.1; -; mRNA EMBL; BC012136; AAH12136.1; -; mRNA CCDS; CCDS10290.1; - RefSeq; NP_665804.1; NM_145805.2 UniGene; Hs.444677; - ProteinModelPortal; Q96A47; - SMR; Q96A47; - BioGrid; 122318; 12 IntAct; Q96A47; 1 STRING; 9606.ENSP00000290759; - iPTMnet; Q96A47; - PhosphoSitePlus; Q96A47; - BioMuta; ISL2; - DMDM; 20978495; - EPD; Q96A47; - MaxQB; Q96A47; - PaxDb; Q96A47; - PeptideAtlas; Q96A47; - PRIDE; Q96A47; - ProteomicsDB; 75911; - DNASU; 64843; - Ensembl; ENST00000290759; ENSP00000290759; ENSG00000159556 GeneID; 64843; - KEGG; hsa:64843; - UCSC; uc002bbw.2; human CTD; 64843; - EuPathDB; HostDB:ENSG00000159556.9; - GeneCards; ISL2; - HGNC; HGNC:18524; ISL2 HPA; HPA075192; - MIM; 609481; gene neXtProt; NX_Q96A47; - OpenTargets; ENSG00000159556; - PharmGKB; PA38566; - eggNOG; KOG0490; Eukaryota eggNOG; ENOG410YIJ3; LUCA GeneTree; ENSGT00760000118921; - HOGENOM; HOG000236304; - HOVERGEN; HBG004671; - InParanoid; Q96A47; - KO; K18492; - OMA; RHDSAVQ; - OrthoDB; EOG091G09L9; - PhylomeDB; Q96A47; - TreeFam; TF315442; - SIGNOR; Q96A47; - GenomeRNAi; 64843; - PRO; PR:Q96A47; - Proteomes; UP000005640; Chromosome 15 Bgee; ENSG00000159556; - CleanEx; HS_ISL2; - ExpressionAtlas; Q96A47; baseline and differential Genevisible; Q96A47; HS GO; GO:0005634; C:nucleus; IC:BHF-UCL GO; GO:0003677; F:DNA binding; ISS:BHF-UCL GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISA:NTNU_SB GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl GO; GO:0048666; P:neuron development; TAS:BHF-UCL GO; GO:0048935; P:peripheral nervous system neuron development; TAS:BHF-UCL GO; GO:0031290; P:retinal ganglion cell axon guidance; IEA:Ensembl GO; GO:0021520; P:spinal cord motor neuron cell fate specification; IEA:Ensembl GO; GO:0021524; P:visceral motor neuron differentiation; IEA:Ensembl CDD; cd00086; homeodomain; 1 InterPro; IPR009057; Homeobox-like_sf InterPro; IPR017970; Homeobox_CS InterPro; IPR001356; Homeobox_dom InterPro; IPR001781; Znf_LIM Pfam; PF00046; Homeobox; 1 Pfam; PF00412; LIM; 2 SMART; SM00389; HOX; 1 SMART; SM00132; LIM; 2 SUPFAM; SSF46689; SSF46689; 1 PROSITE; PS00027; HOMEOBOX_1; 1 PROSITE; PS50071; HOMEOBOX_2; 1 PROSITE; PS00478; LIM_DOMAIN_1; 2 PROSITE; PS50023; LIM_DOMAIN_2; 2 1: Evidence at protein level; Complete proteome; Developmental protein; DNA-binding; Homeobox; LIM domain; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Zinc CHAIN 1 359 Insulin gene enhancer protein ISL-2 /FTId=PRO_0000075752 DOMAIN 25 86 LIM zinc-binding 1. {ECO:0000255|PROSITE- ProRule:PRU00125} DOMAIN 87 149 LIM zinc-binding 2. {ECO:0000255|PROSITE- ProRule:PRU00125} DNA_BIND 191 250 Homeobox. {ECO:0000255|PROSITE- ProRule:PRU00108} REGION 272 301 LIM-binding domain (LID). MOD_RES 154 154 Phosphoserine MOD_RES 157 157 Phosphoserine MOD_RES 279 279 Phosphoserine SEQUENCE 359 AA; 39768 MW; 2162FB3D430EE4BE CRC64; MVDIIFHYPF LGAMGDHSKK KPGTAMCVGC GSQIHDQFIL RVSPDLEWHA ACLKCAECSQ YLDETCTCFV RDGKTYCKRD YVRLFGIKCA KCQVGFSSSD LVMRARDSVY HIECFRCSVC SRQLLPGDEF SLREHELLCR ADHGLLLERA AAGSPRSPGP LPGARGLHLP DAGSGRQPAL RPHVHKQTEK TTRVRTVLNE KQLHTLRTCY AANPRPDALM KEQLVEMTGL SPRVIRVWFQ NKRCKDKKKS ILMKQLQQQQ HSDKTSLQGL TGTPLVAGSP IRHENAVQGS AVEVQTYQPP WKALSEFALQ SDLDQPAFQQ LVSFSESGSL GNSSGSDVTS LSSQLPDTPN SMVPSPVET
Research Areas
Citations (0)

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ISL2 is a transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways (By similarity).


Li, Y., et al. Mol. Biol. Rep. 34(1):19-26(2007)Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)Jurata, L.W., et al. J. Biol. Chem. 273(6):3152-3157(1998)

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$ 80.00
Cat# BP16528b
Availability: In Stock
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