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GPR37L1 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O60883
Clone Names 100603326
Additional Information
Gene ID 9283
Other Names Prosaposin receptor GPR37L1, Endothelin B receptor-like protein 2, ETBR-LP-2, G-protein coupled receptor 37-like 1, GPR37L1, ETBRLP2
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPR37L1
Synonyms ETBRLP2
Function G-protein coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594). However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein. Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q99JG2}; Multi-pass membrane protein. Note=Associates with the basal membrane of Bergmann glia cell primary cilia. {ECO:0000250|UniProtKB:Q99JG2}
Tissue Location Expressed in primary cortical astrocytes (at protein level) (PubMed:23690594). Expressed in the central nervous system (PubMed:9539149).
Research Areas
Citations (0)
citation

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Background

GPR37L1 is orphan receptor.

References

Davila, S., et al. Genes Immun. 11(3):232-238(2010)Arking, D.E., et al. PLoS ONE 5 (3), E9879 (2010) :Valdenaire, O., et al. FEBS Lett. 424(3):193-196(1998)

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$ 277.78
Cat# BP16532a
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