|Other Names||3'(2'), 5'-bisphosphate nucleotidase 1, Bisphosphate 3'-nucleotidase 1, PAP-inositol 1, 4-phosphatase, PIP, BPNT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4- trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.|
|Tissue Location||Highly expressed in kidney, liver, pancreas and heart. Detected at lower levels in brain, placenta, lung and skeletal muscle.|
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BPNT1, also called bisphosphate 3-prime-nucleotidase, orBPntase, is a member of a magnesium-dependent phosphomonoesterasefamily. Lithium, a major drug used to treat manic depression, actsas an uncompetitive inhibitor of BPntase. The predicted humanprotein is 92% identical to mouse BPntase. BPntase's physiologicrole in nucleotide metabolism may be regulated by inositolsignaling pathways. The inhibition of human BPntase may account forlithium-induced nephrotoxicity.
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :Spiegelberg, B.D., et al. J. Biol. Chem. 274(19):13619-13628(1999)
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