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BPNT1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O95861
Clone Names 100617026
Peptide ID 100617026
Additional Information
Gene ID 10380
Other Names 3'(2'), 5'-bisphosphate nucleotidase 1, Bisphosphate 3'-nucleotidase 1, PAP-inositol 1, 4-phosphatase, PIP, BPNT1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BPNT1
Function Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4- trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.
Tissue Location Highly expressed in kidney, liver, pancreas and heart. Detected at lower levels in brain, placenta, lung and skeletal muscle.
Research Areas
Citations (0)

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BPNT1, also called bisphosphate 3-prime-nucleotidase, orBPntase, is a member of a magnesium-dependent phosphomonoesterasefamily. Lithium, a major drug used to treat manic depression, actsas an uncompetitive inhibitor of BPntase. The predicted humanprotein is 92% identical to mouse BPntase. BPntase's physiologicrole in nucleotide metabolism may be regulated by inositolsignaling pathways. The inhibition of human BPntase may account forlithium-induced nephrotoxicity.


Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :Spiegelberg, B.D., et al. J. Biol. Chem. 274(19):13619-13628(1999)

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$ 80.00
Cat# BP16536b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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