|Other Names||SLIT and NTRK-like protein 4, SLITRK4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Suppresses neurite outgrowth.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in the cerebral cortex of the brain and at higher levels in some astrocytic brain tumors such as astrocytomas, glioblastomas and primitive neuroectodermal tumors|
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This gene encodes a transmembrane protein belonging to thethe SLITRK family. These family members include two N-terminalleucine-rich repeat domains similar to those found in the axonalgrowth-controlling protein SLIT, as well as C-terminal regionssimilar to neurotrophin receptors. Studies of an homologous proteinin mouse suggest that this family member functions to suppressneurite outgrowth. Alternative splicing results in multipletranscript variants.
Aruga, J., et al. Gene 315, 87-94 (2003) :Aruga, J., et al. Mol. Cell. Neurosci. 24(1):117-129(2003)
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