|Other Names||DNA mismatch repair protein Msh3, hMSH3, Divergent upstream protein, DUP, Mismatch repair protein 1, MRP1, MSH3, DUC1, DUG|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion- deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene forms a heterodimer withMSH2 to form MutS beta, part of the post-replicative DNA mismatchrepair system. MutS beta initiates mismatch repair by binding to amismatch and then forming a complex with MutL alpha heterodimer.Defects in this gene are a cause of susceptibility to endometrialcancer.
Monsees, G.M., et al. Breast Cancer Res. Treat. 125(1):207-214(2011)Lee, S.Y., et al. Gastroenterology 139(5):1519-1525(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Kumarasinghe, A.P., et al. Pathology 42(5):414-420(2010)
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