|Other Names||Steroidogenic acute regulatory protein, mitochondrial, StAR, START domain-containing protein 1, StARD1, STAR, STARD1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.|
|Tissue Location||Expressed in gonads, adrenal cortex and kidney|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene plays a key role in theacute regulation of steroid hormone synthesis by enhancing theconversion of cholesterol into pregnenolone. This protein permitsthe cleavage of cholesterol into pregnenolone by mediating thetransport of cholesterol from the outer mitochondrial membrane tothe inner mitochondrial membrane. Mutations in this gene are acause of congenital lipoid adrenal hyperplasia (CLAH), also calledlipoid CAH. A pseudogene of this gene is located on chromosome 13.
Shi, F.T., et al. J. Clin. Endocrinol. Metab. 95 (10), E172-E180 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Mizutani, T., et al. J. Biol. Chem. 285(36):28240-28251(2010)Sahakitrungruang, T., et al. J. Clin. Endocrinol. Metab. 95(7):3352-3359(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
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